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. 2020 Oct 22;10:18028. doi: 10.1038/s41598-020-74482-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcription factors associated with the E2F4-enriched module. Transcription factors with Enrichr q-value < 0.05 and t-test p < 0.05 between recurrent and non-recurrent tumors in both validation cohorts are included. Red corresponds to validation cohort 1 (microarray) and blue corresponds to validation cohort 2 (RNA-sequencing). ANOVA p-values for gene association with WHO grade are found on the plot, with colour corresponding to boxplot colours. Note that DEPDC1 and NFKB1 are not significantly associated with WHO grade in validation cohort 1, SUZ12 and RUNX1 are not significantly associated with WHO grade in validation cohort 2, and that TWIST1 is not significantly associated with WHO grade in either validation cohort.