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. Author manuscript; available in PMC: 2020 Oct 23.
Published in final edited form as: Free Radic Biol Med. 2019 Dec 20;147:200–211. doi: 10.1016/j.freeradbiomed.2019.12.019

Fig. 6.

Fig. 6.

Proposed mechanism of SmTGR inhibition by 2NAMOs. The major routes of SmTGR inhibition by 1 and 4 are displayed. The formation of oQM by compounds 1 and 4 followed by covalent modification of the protein is in accordance with irreversible and NADPH-dependent inhibition mechanism observed for this class of compounds. The oQM, generated by 4 in the 2NAMO binding site, can be sequestered by the mobile reduced C-terminal arm.