Table 2.

Activity of compounds against live, cultured worms. Compounds were added to media and worm survival was quantitated at indicated times.

Compound	IC50 (μM)	Adult S. mansoni (144 h)		Larval S. mansoni(120 h)
		50 μM	10 μM	10 μM
1	0.61 ± 0.09	13% dead	8% dead	n.d.a
2	0.65 ± 0.12	5% dead	n.d.a	n.d.a
3	0.84 ± 0.03	24% dead	0% dead	19% dead
4	11.2 ± 1.9	0% dead	0% dead	n.d.a
6	57.63 ± 4.57	0% dead	n.d.a	n.d.a

^an.d. – not determined.