Table 1.

The characteristics of included studies in current meta-analysis.

First author, year	Country	Ethnicity	Sample size	Genotypes (wtwt/wtmt/mtmt)		P-value for HWE	NOS score
				Cases	Controls
ApaI rs7975232
Ahmad 2018	India	Mixed	254/254	62/140/52	75/134/45	0.264	7
Castelán-Martínez 2015	Mexico	Mixed	387/147	141/160/86	46/75/26	0.631	7
Chen 2007	China	Asian	155/113	108/40/7	60/41/12	0.223	7
Dabirnia 2016	Iran	Mixed	50/50	24/25/1	30/18/2	0.729	7
Douroudis 2003	Hellenic Republic	Caucasian	35/44	11/14/10	17/26/1	0.016	7
Duman 2004	Turkey	Caucasian	75/66	13/56/6	15/45/6	0.002	7
Dundar 2009	Turkey	Caucasian	112/24	26/61/25	8/14/2	0.231	7
Ge 2009	China	Asian	353/208	160/157/36	102/84/22	0.453	8
González-Mercado 2013	Mexico	Mixed	232/87	79/118/35	29/41/17	0.715	7
Gu 2010	China	Asian	186/148	79/86/21	74/61/13	0.932	7
Iván 2008	Chile	Caucasian	67/59	25/31/11	18/27/14	0.536	7
Kim 2015	Korea	Asian	153/47	97/53/3	24/19/4	0.931	7
Langdahl 2000	Denmark	Caucasian	78/74	22/44/12	25/32/17	0.283	7
Liang 2002	China	Asian	30/30	20/6/4	27/2/1	0.011	7
Luan 2011	China	Asian	140/88	71/56/13	44/34/10	0.390	7
Marozik 2013	Belarus	Caucasian	54/77	7/24/23	29/34/14	0.472	7
Marozik 2018	Lithuania	Caucasian	149/172	27/67/55	60/74/38	0.105	7
Meng 2018	China	Asian	90/246	60/25/5	161/69/16	0.028	8
Mitra 2006	India	Mixed	119/97	50/44/25	34/33/30	0.002	7
Mosaad 2014	Egypt	Mixed	30/150	13/15/2	69/71/10	0.142	7
Riggs 1995	USA	Mixed	30/128	12/19/9	38/59/31	0.394	7
Sassi 2015	Tunisia	Mixed	335/231	130/143/62	90/115/26	0.233	7
Seremak-Mrozikiewicz 2009	Poland	Caucasian	163/63	35/82/46	12/32/19	0.821	7
Tanriover 2010	Turkey	Caucasian	50/50	15/23/12	22/15/13	0.007	8
Uysal 2008	Turkey	Caucasian	100/146	35/50/15	46/79/21	0.165	7
Vandevyver 1997	Belgium	Caucasian	87/699	20/45/22	197/375/127	0.027	8
Wu 2016	China	Asian	79/234	43/27/9	105/111/18	0.123	7
Wu 2019	China	Asian	610/616	331/218/61	366/207/43	0.070	8
Xie 2005	China	Asian	295/56	240/43/12	34/16/6	0.075	7
Yoldemir 2011	Turkey	Caucasian	130/130	34/60/36	31/73/26	0.155	7
Zajickova 2002	Czech Republic	Caucasian	65/33	23/33/9	10/17/6	0.793	7
BsmI rs1544410
Ahmad 2018	India	Mixed	254/254	54/137/63	54/152/48	0.002	7
Berg 1996	Norway	Caucasian	19/30	4/8/7	8/11/11	0.156	7
Boroń 2015	Poland	Caucasian	278/292	101/121/56	128/113/51	0.004	7
Cheishvili 2017	Israel	Mixed	37/37	13/11/13	15/12/10	0.039	7
Chen 2003	China	Asian	78/81	65/13/0	69/12/0	0.472	7
Douroudis 2003	Hellenic Republic	Caucasian	35/44	20/12/3	29/10/5	0.019	7
Duman 2004	Kuwait	Mixed	75/66	54/18/3	42/17/7	0.021	7
Efesoy 2011	Turkey	Caucasian	40/30	12/23/5	10/15/5	0.876	7
Ge 2009	China	Asian	353/208	314/33/6	192/12/4	<0.001	8
Gennari 1998	Italy	Caucasian	155/136	23/92/40	49/76/11	0.013	7
González-Mercado 2013	Mexico	Mixed	232/88	143/76/13	46/38/4	0.267	7
Houston 1996	UK	Caucasian	44/44	17/19/8	16/19/9	0.450	7
Huang 2000	China	Asian	14/27	13/1/0	26/1/0	0.922	7
Hussien 2013	Egypt	Mixed	150/50	50/57/43	19/21/10	0.351	7
Iván 2008	Chile	Caucasian	67/59	10/46/11	13/37/9	0.046	7
Kim 2015	Korea	Asian	153/47	142/11/0	42/5/0	0.700	7
Langdahl 2000	Denmark	Caucasian	80/80	23/38/19	25/34/21	0.186	7
Li 2000	China	Asian	96/42	54/36/6	20/21/1	0.095	7
Liang 2002	China	Asian	30/30	28/1/1	30/0/0	NA	7
Lim 1995	Korea	Asian	72/70	61/9/2	60/9/1	0.349	7
Liu 2005	China	Asian	56/89	50/6/0	76/11/2	0.060	7
Marozik 2013	Belarus	Caucasian	54/77	11/31/12	40/26/11	0.062	7
Marozik 2018	Lithuania	Caucasian	149/172	32/64/53	64/73/35	0.098	7
Melhus 1994	Sweden	Caucasian	70/76	14/29/27	34/35/7	0.637	8
Mencej-Bedrac 2009	Slovenia	Caucasian	240/228	103/110/27	88/100/40	0.215	8
Meng 2017	China	Asian	90/246	74/12/4	216/24/6	<0.001	7
Mitra 2006	India	Mixed	119/97	51/46/22	40/38/19	0.080	7
Mosaad 2014	Egypt	Mixed	30/150	2/19/9	36/74/40	0.877	7
Musumeci 2009	Iran	Mixed	50/20	27/15/8	17/2/1	0.047	7
Perez 2008	Argentina	Mixed	64/68	17/35/12	20/32/16	0.649	7
Pollak 2001	Israel	Mixed	75/143	24/38/13	60/67/16	0.675	7
Pouresmaeili 2013	Iran	Mixed	64/82	17/33/14	36/33/13	0.252	7
Riggs 1995	USA	Mixed	40/129	9/20/11	20/61/48	0.932	7
Seremak-Mrozikiewicz 2009	Poland	Caucasian	163/63	70/66/27	26/27/10	0.506	7
Tanriover 2010	Turkey	Caucasian	50/50	16/19/15	24/19/7	0.320	8
Techapatiphandee 2018	Thailand	Asian	105/132	85/19/1	103/25/4	0.123	7
Uysal 2008	Turkey	Caucasian	100/146	18/48/34	24/78/44	0.283	7
Vandevyver 1997	Belgium	Caucasian	86/698	24/50/12	203/368/127	0.076	8
Wang 2007	China	Asian	50/48	43/7/0	39/9/0	0.474	7
Yanagi 1996	Japan	Asian	66/66	22/12/12	57/7/2	0.013	7
Yoldemir 2011	Turkey	Caucasian	130/130	35/73/22	43/65/22	0.760	7
Zajickova 2002	Czech Republic	Caucasian	65/33	20/24/21	10/13/10	0.223	7
Zhang 1998	China	Asian	17/164	14/3/0	148/16/0	0.511	8
Zhang 2000	China	Asian	77/35	38/33/6	14/18/3	0.403	7
Zhu 2004	China	Asian	40/158	26/8/6	105/46/7	0.500	7
FokI rs10735810
Ahmad 2018	India	Mixed	254/254	148/92/14	169/80/5	0.20	7
Castelán-Martínez 2015	Mexico	Mixed	232/88	61/118/53	24/45/19	0.807	7
Choi 2000	Korea	Asian	48/65	12/23/13	26/33/6	0.327	7
González-Mercado 2013	Mexico	Mixed	88/88	25/48/15	24/45/19	0.807	7
Gu 2010	China	Asian	186/148	46/100/40	40/84/24	0.071	7
Iván 2008	Chile	Caucasian	67/59	29/27/11	27/25/7	0.744	7
Kanan 2013	Jordan	Mixed	120/90	40/62/18	29/48/13	0.336	7
Kim 2015	Korea	Asian	153/47	50/83/20	14/25/8	0.577	7
Langdahl 2000	Denmark	Caucasian	30/128	12/19/9	38/59/31	0.394	7
Li 2019	China	Asian	224/155	66/103/55	58/68/29	0.259	7
Lisker 2003	Mexico	Mixed	65/57	27/29/9	20/29/8	0.625	7
Lucotte 1999	France	Caucasian	124/105	45/69/10	40/52/13	0.535	7
Mamolini 2017	Italy	Caucasian	170/73	97/60/13	40/25/8	0.194	7
Mansour 2010	Iran	Mixed	50/20	34/9/7	20/0/0	NA	7
Mencej-Bedrac 2009	Slovenia	Caucasian	240/228	88/108/44	105/97/26	0.618	8
Mitra 2006	India	Mixed	119/97	38/42/39	46/33/18	0.011	7
Mohammadi 2015	Iran	Mixed	96/356	52/36/8	198/128/30	0.158	7
Mosaad 2014	Egypt	Mixed	30/150	23/6/1	93/55/2	0.049	7
Pérez 2008	Argentina	Mixed	64/68	22/32/10	22/36/10	0.444	7
Tanriover 2010	Turkey	Caucasian	50/50	27/22/1	29/18/3	0.926	8
Techapatiphandee 2018	Thailand	Asian	105/132	31/46/28	41/73/18	0.106	7
Wu 2019	China	Asian	610/616	296/235/79	404/186/26	0.436	8
Xing 2011	China	Asian	32/70	7/14/11	27/35/8	0.506	7
Yasovanthi 2011	India	Mixed	247/254	104/119/24	122/124/8	<0.001	8
Yoldemir 2011	Turkey	Caucasian	130/130	66/55/9	62/55/13	0.876	7
Zajickova 2002	Czech Republic	Caucasian	78/74	22/44/12	25/32/17	0.283	7
TaqI rs731236
Ahmad 2018	India	Mixed	254/254	124/96/34	89/123/42	0.964	7
Dabirnia 2016	Iran	Mixed	50/50	20/24/6	16/29/5	0.121	7
Duman 2004	Kuwait	Mixed	75/66	10/42/23	15/28/23	0.259	7
Gennari 1998	Italy	Caucasian	160/144	33/87/40	62/71/11	0.126	7
González-Mercado 2013	Mexico	Mixed	232/88	142/77/13	46/36/6	0.769	7
Iván 2008	Chile	Caucasian	67/59	26/31/10	17/34/8	0.167	7
Kim 2015	Korea	Asian	153/47	140/12/1	42/5/0	0.700	7
Langdahl 2000	Denmark	Caucasian	46/284	11/30/5	91/159/34	0.005	7
Larin 2015	Ukraine	Caucasian	44/30	20/18/6	14/12/4	0.584	7
Marozik 2013	Belarus	Caucasian	54/77	17/26/11	39/24/14	0.008	7
Marozik 2018	Lithuania	Caucasian	149/172	38/62/49	58/74/40	0.088	7
Masi 1998	Italy	Caucasian	90/111	41/36/13	38/64/9	0.013	7
Mitra 2006	India	Mixed	119/97	34/42/43	44/31/22	0.001	7
Mosaad 2014	Egypt	Mixed	30/150	9/19/2	39/74/37	0.872	7
Riggs 1995	USA	Mixed	31/130	11/23/7	53/57/20	0.475	7
Sassi 2015	Tunisia	Mixed	335/231	165/128/42	103/95/33	0.152	7
Seremak-Mrozikiewicz 2009	Poland	Caucasian	163/63	78/59/26	22/29/12	0.659	7
Tanriover 2010	Turkey	Caucasian	50/50	15/29/6	25/17/8	0.102	8
Techapatiphandee 2018	Thailand	Asian	105/132	97/6/2	116/15/1	0.513	7
Uysal 2008	Turkey	Caucasian	100/146	40/46/14	54/75/17	0.237	7
Vandevyver 1997	Belgium	Caucasian	46/284	11/30/5	91/159/34	0.005	8
Wang 2013	China	Asian	92/98	47/48/7	48/40/10	0.698	7
Yoldemir 2011	Turkey	Caucasian	130/130	51/59/20	49/59/22	0.558	7
Zajickova 2002	Czech Republic	Caucasian	65/33	11/31/23	8/14/11	0.407	7
Ziablitsev 1994	Ukraine	Caucasian	44/30	20/18/6	14/12/4	0.584	7

HWE, Hardy–Weinberg equilibrium; mt, Mutant type; NA, not available; NOS, Newcastle-Ottawa scale; wt, Wild type;.