Table 3.
Body weight, BMI and measures of disease activity and function before weight loss treatment at baseline (BL) and after 12-months (M12) and 24-months (M24) in patients with psoriatic arthritis (PsA). Values are median and inter-quartile range (IQR)
| BL N = 39 |
M12 N = 39 |
M24 N = 35 |
BL vs M12 p-value N = 39 |
BL vs M24 p-value N = 35 |
|
|---|---|---|---|---|---|
| Body weight kg | 106.0 (93.5–112.5) | 87.5 (80.6–95.5) | 92.7 (85.7–100.7) | < 0.001 | < 0.001 |
| BMI kg/m2 | 35.2 (33.9–37.9) | 30.5 (28.0–32.9) | 32.3 (30.3–35.4) | < 0.001 | < 0.001 |
| Tender joints 68 count | 4 (1–14) | 3 (0–6) | 2 (0–7) | 0.001 | < 0.001 |
| Swollen joints 66 count | 0 (0–1) | 0 (0–1) | 0 (0–0) | 0.015 | 0.003 |
| Leeds enthesitis index, count | 1 (0–4) | 0 (0–2) | 1 (0–3) | < 0.001 | 0.002 |
| BSA % | 0.75 (0–2) | 0.25 (0–1) | 0.25 (0–1.5) | 0.018 | 0.194 |
| CRP mg/L | 5 (3–9) | 2 (1–5) | 3 (2–5) | 0.009 | 0.011 |
| Hb g/L | 144 (131–150) | 143 (131–150) | 142 (135–149) | 0.296 | 0.537 |
| WBC 109/L | 6.1 (5.3–7.7) | 5.7 (5.0–7.4) | 5.9 (4.7–7.8) | 0.133 | 0.346 |
| PLT 109/L | 270 (202–299) | 262 (203–308) | 273 (220–332) | 0.368 | 0.334 |
| VAS Pain mm | 35 (15–60) | 30 (14–46) | 35 (15–55) | 0.073 | 0.799 |
| VAS Global health, mm | 40 (20–70) | 30 (17–52) | 40 (20–60) | 0.023 | 0.282 |
| VAS Fatigue mm | 50 (30–70) | 30 (20–60) | 60 (30–80) | 0.021 | 0.064 |
| HAQ score | 0.63 (0.13–1.00) | 0.25 (0–0.63) | 0.25 (0.13–0.88) | 0.002 | 0.033 |
| BASFI score | 2.6 (1.4–5.2) | 1.6 (0.57–3.6) | 2.1 (0.9–4.2) | < 0.001 | 0.131 |
| DLQI score | 1 (0–4) | 1 (0–4) | 1 (0–4) | 0.380 | 0.982 |
| DAS-28CRP score | 3.1 (2.1–3.7) | 2.4 (1.8–3.3) | 2.4 (1.7–2.9) | < 0.001 | < 0.001 |
| DAPSA score | 16.1 (6.2–23.3) | 9.5 (4.8–18.1) | 9.7 (5.3–19.0) | < 0.001 | < 0.001 |
| MDA n (%) | 11 (28.2) | 15 (38.5) | 16 (45.7) | 0.008 | 0.016 |
BASFI = Bath Ankylosing Spondylitis Functional Index, BMI = Body Mass Index, BSA = Body Surface Area, CRP = C- reactive protein, DAPSA = Disease Activity in PSoriatic Arthritis, DAS28CRP = Disease Activity Score using 28 joint counts based on CRP, DLQI = Dermatology Life Quality Index, ESR = erythrocyte sedimentation rate, HAQ = Health Assessment Questionnaire, Hb = hemoglobin, MDA = Minimal Disease Activity, PLT = platelet count, VAS = Visual Analogue Scale, WBC = White Blood Cell count