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. 2020 Oct 22;11(10):898. doi: 10.1038/s41419-020-03107-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A, B The RNA level of ClC-3 was significantly abundant compared with other ClC chloride channel superfamily members (n = 3). C The heatmap of RNA sequencing revealed that 60 same genes were correspondingly down-regulated in the two ClC-3 KD cells, of which the SGK1 gene was the mostly down-regulated. D, E The RNA levels of ClC-3 and SGK1 were significantly reduced in the two ClC-3 KD cells (n = 3). F The protein levels of ClC-3 and SGK1 were significantly decreased in the two ClC-3 KD cells (n = 3). shNC negative control shRNA, shClC-3-1 ClC-3 knockdown shRNA-1, shClC-3-2 ClC-3 knockdown shRNA-2. *P < 0.05.