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. 2020 Oct 22;11(10):898. doi: 10.1038/s41419-020-03107-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B Up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced cell invasion and migration inhibition, and the enhancement effect could be attenuated by SGK1 KD (n = 3). C Typical time courses of the chloride current recorded by whole-cell patch clamp. The results indicated that the chloride current activated by olaparib was increased in ClC-3 OV SGC-7901 cells, and the increase effect could be attenuated by SGK1 KD (n = 3). D Current density analysis indicated that the chloride current density activated by olaparib was increased in ClC-3 OV SGC-7901 cells, and the increase effect could be attenuated by SGK1 KD (n = 3). *P < 0.05.