Table 1.
Patient characteristics
| Controls | T2DM without LGE | T2DM with ischemic LGEa | T2DM with non-ischemic LGE | P valueb | P valuec | |
|---|---|---|---|---|---|---|
| Number | 25 | 207 | 32 | 25 | – | – |
| Age, years | 57 IQR50–64 | 59 IQR50–67 | 64 IQR56–69.5 | 64 IQR57–72 | 0.008 | 0.06 |
| Body mass index, kg/m2 | 25.1 ± 3.3 | 31.0 ± 4.7 | 31.9 ± 4.9 | 30.8 ± 3.7 | < 0.001 | 0.8 |
| Male sex (n,%) | 17 (68) | 140 (68) | 24 (75) | 23 (92) | 0.08 | – |
| Diabetes duration, years | – | 12.2 ± 8.2 | 12.4 ± 8.0 | 15.4 ± 9.0 | 0.20 | – |
| Systolic blood pressure, mmHg | 133 ± 16 | 134 ± 18 | 142 ± 21 | 142 ± 14 | 0.04 | 0.06 |
| Diastolic blood pressure, mmHg | 81 ± 10 | 81 ± 9 | 82 ± 13 | 81 ± 9 | 0.98 | – |
| Active or former smoker (n,%) | 11 (44) | 135 (65) | 29 (91) | 16 (64) | 0.003 | 1.0 |
| History of ischemic heart disease (n,%) | – | 15 (7) | 26 (81) | 3 (12) | < 0.001 | 0.4 |
| History of hypertension (n,%) | 4 (25) | 137 (66) | 28 (87.5) | 21 (84) | < 0.001 | 0.07 |
| NYHA class II/III (n,%) | – | 41 (20) | 8 (25) | 6 (24) | 0.82 | – |
| Insulin treatment (n,%) | – | 120 (58) | 18 (56) | 18 (72) | 0.38 | – |
| HbA1c, mmol/mol | 35 ± 3 | 62 ± 15 | 62 ± 16 | 64 ± 14 | < 0.001 | 0.65 |
| Creatinine, µmol/L | 86 IQR67–89 | 71 IQR59–86 | 75 IQR65–87 | 74 IQR65–90 | 0.052 | – |
| LDL cholesterol, mmol/L | 3.0 IQR2.2–3.7 | 1.9 IQR1.5–2.5 | 1.4 IQR1.2–2.0 | 1.8 IQR1.3–2.8 | 0.0001 | 0.68 |
| High–sensitive CRP, mg/L | – | 2.1 IQR1.0–4.3 | 2.3 IQR1.0–4.0 | 2.5 IQR1.3–5.2 | 0.57 | – |
| Pro-BNP, µmol/L | – | 5.9 IQR5.9–10.1 | 8.0 IQR5.9–17.3 | 8.9 IQR5.9–19.7a | 0.02 | 0.02 |
| High-sensitive TNT, ng/L | – | 13.0 IQR13.0–14.6 | 13.6 IQR13.0–17.6 | 15.6 IQR13.0–26.1a | 0.008 | 0.0007 |
| Pro-ANP, µmol/L | – | 57 IQR42–90 | 108 IQR47–174 | 75.5 IQR48–127 | 0.01 | 0.1 |
Data presented as median and interquartile range (IQR) or as nominal values with percentages in parentheses
aIncluding three patients with both ischemic and non-ischemic lesions
bComparison between all three groups as appropriate
cComparison between T2DM patients with non-ischemic LGE vs. T2DM patients without LGE