Figure 6.

Simulation of Ca²⁺ waves in three representative models of the control population (models #1, #7, and #15). Traces on left hand-side show the APs (top), CaTs (bottom) at the membrane (CaT_m, black lines) and centre of cell (CaT_c, red lines). The right hand-side of the Figure shows line scans of propagating Ca²⁺ waves in 3 simulated beats at 2 Hz pacing. The black and red boxes on the top-right panel show the domains corresponding to the CaT_m and CaT_c traces. Model #1 shows a propagating Ca²⁺ wave where CaT_m and CaT_c have rather similar morphologies; model #15 shows a Ca²⁺ wave with slightly larger CaT_delay; and model #7 shows a wave patterns with decreased CaTA_c as compared to CaTA_m.