FIGURE 1.

Experimental protocol assayed here for diffusion tensor distribution (DTD) imaging at high spatial resolution. (A) Pulse sequence combining tensor‐valued diffusion encoding with a 2D SPatiotemporal ENcoding (SPEN) acquisition scheme. Diffusion encoding is performed by a set of continuous, self‐refocused gradient waveforms, with duration T _diff, allowing for separate control over the magnitude b, normalized anisotropy b _∆ and orientation (Θ, Φ) of the diffusion‐encoding tensor b. ³⁴ The pulse sequence timing is illustrated under conditions that fulfill SPEN's full refocusing condition; to this effect, an additional delay (T _d+) was introduced, if/when the length of the diffusion‐encoding gradient waveform exceeded T _a/2. (B) Set of gradient waveforms used in this work. Each waveform was designed to give a distinct value of b _∆, as per manipulations of the three orthogonal (color‐coded) gradients