FIGURE 7.

SPEN DTD parameter maps of phantoms designed to give diffusion properties similar to the white matter, gray matter and cerebrospinal fluid components in in vivo mouse brain. Phantom and in vivo data were acquired with the same hardware, imaging parameters and DTD acquisition protocol as reported in Figure 3 and Table 1. Row 1: hex ⁵¹ (anisotropic) phantom, row 2: dodecane (slow isotropic) phantom, row 3: water (fast isotropic) phantom, row 4: in vivo mouse brain. The parameter maps are as explained in Figures 4 and 5. Note that for the phantoms, all heterogeneity measures Var[D _iso], Var[D _Δ ²] and Cov[D _iso,D _Δ ²] are zero and that all DTD components fall within the intended bins: Thin: hex phantom, Thick: dodecane, and Big: water