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. 2020 Oct 20;12(1):125–144. doi: 10.1080/21645698.2020.1831729

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Graphical repersentation how CRISPR-Cas9 system work as bacterial immune system

Infection. After infection, virus injedct its genome into the host, Adaptaion viral genome is acquired by CRISPR array (colored boxes; spacers and repeats) using Cas proteins; crRNA biogenesis Pre- Pre-crRNA is transcribed from the leader region by RNA polymerase and further cleaved into smaller crRNAs that contain a single spacer and a partial repeat by Cas proteins. Interference. crRNA containing a spacer that has a strong match to attacking virus genome initiates a cleavage event using Cas proteins are required for this process and interferes with virus replication.