Table 1.

Patient characteristics in four frail older patients who received FMT as a home treatment. The MPI is a cumulative frailty assessment tool validated in a Danish department of geriatrics, and individual scores were converted to low, moderate or severe degree of frailty

No.	Gender, age	Previous history	Incident	Frailty level	Antibiotics before CDI	Initial CDI presentation	Clinical course following FMT
1	Female 85 years	Atrial fibrillation, hypothyroidism, upper gastrointestinal bleeding	Chest pain and fever, cholangitis	Severe	Piperacillin-tazobactam, ciprofloxacin, cefuroxim, pivmecillinam	Severe, C. difficile toxin A/B, initial resolution. Recurrence within 1 week, severe CDI with abdominal pain, refractory to vancomycin	Tube-delivered FMT with complete recovery and negative C. difficile test
2	Female 93 years	Hypertension, atrial fibrillation, recent stroke	Fall with rhabdomyolysis	Severe	Cefuroxim, pivmecillinam	Severe, C. difficile toxin A/B, refractory to metronidazole and vancomycin, with general deterioration. Severe bradycardia, but pacemaker implantation not possible due to CDI	Tube-delivered FMT with instant improvement. Pacemaker inserted. Recurrence following prophylactic antibiotics. Second FMT delivered by capsules, complete recovery
3	Male 88 years	Atrial fibrillation, biological aortic valve, ischaemic heart disease	Fall and wound infection	Severe	Dicloxacillin, penicillin, cefuroxim, meropenem, trimopan	Severe, C. difficile toxin A/B, initial resolution with metronidazole. Recurrence after 2 weeks, rapid decline despite vancomycin	Tube-delivered FMT with clinical resolution. Recurrence after 2 months, vancomycin no effect. Capsule FMT for refractory CDI with complete recovery
4	Female 92 years	Hypertension, diabetes mellitus, polymyalgia, renal failure	Fall with rhabdomyolysis, hip fracture	Severe	Piperacillin-tazobactam	Severe, C. difficile toxin A/B, no effect of vancomycin, deterioration with immobilisaiton, anorexia, confusion, leukocytosis	Tube-delivered FMT, complete recovery. Recurrence following pivmecillinam for UTI, improvement with vancomycin. Feared further recurrences, established on long-term vancomycin