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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Methods Mol Biol. 2021;2219:195–216. doi: 10.1007/978-1-0716-0974-3_12

Figure 1.

Figure 1.

Three large Xenopus oocyte nuclei and three small follicle cell nuclei hybridized with 3H-radiolabeled rRNA. This is one of the first images on in situ hybridization. Note the small intense black spots (silver grains) indicating sites of probe binding to rDNA that becomes progressive more abundant with growth of the oocyte (seen by increased size of the nuclei [4]. The follicle cell nuclei do not have significant rDNA amplification and are largely signal negative. The image was a re-photograph of the slide originally made in 1969.