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. Author manuscript; available in PMC: 2021 Jul 8.
Published in final edited form as: Circ Heart Fail. 2020 Jul 8;13(7):e006935. doi: 10.1161/CIRCHEARTFAILURE.120.006935

Figure 3 -. Lack of Nexilin in adult cardiomyocytes alters calcium dynamics.

Figure 3 -

(A) representative Ca2+ transient curve; and (B-C) histograms showing results from quantifications of Ca2+ transient (B) amplitude of the peak (ΔF/F0) and (C) transient decay (Tau) of live cardiomyocytes isolated from CTRL and icKO ventricles, 2 weeks after tamoxifen treatment. (D) Representative graph of cardiomyocyte sarcomere length measurement. (E) Graphs showing measurements of sarcomere length shortening percentage and (F) sarcomere relaxation time (Tau). Cardiomyocytes were labeled with Fura2-AM (n=6 mice). (G) Western blot representative images and (H) relative quantification graphs of Nexilin and Ca2+-handling proteins expression in CTRL and icKO ventricles lysates, 2 weeks after tamoxifen treatment. (*) Statistically significant differences with P value < 0.05.