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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Transmembrane forms of PrPc. The transmembrane forms of PrPc, NtmPrPc and CtmPrPc, span the lipid bilayer once through the hydrophobic domain with either C-terminal or N-terminal, respectively on the cytosol side of endoplasmic reticulum (ER). C* represents the correctly positioned PrPc.