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. 2020 Sep 29;21(19):7211. doi: 10.3390/ijms21197211

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Survival analysis based on a combination of microRNA levels in total serum (t.s.) and/or SEC + CD44 EVs (combinations: miR-15b-3p in t.s. plus (A): miR-21-3p in SEC + CD44 EVs; (B): miR-106a-5p in SEC + CD44 EVs; (C): miR-328-3p in SEC + CD44 EVs). Depicted are survival curves using a dichotomous assessment from glioblastoma patients (n = 55) in both SEC + CD44 separated serum EVs and total serum. Blue color indicates patients whose microRNA profile fulfils both conditions, while red color indicates patients whose profile fulfils at most one out of two conditions. Note that the combination of miR-15b-3p in serum with each of these four microRNAs in SEC + CD44 EVs allowed for a prognostic stratification of this patient population, even after Benjamini–Hochberg correction (Table S1).