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. 2020 Oct 22;8(2):e001358. doi: 10.1136/jitc-2020-001358

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Tumor-infiltrating cells (TICs) in YTN2 and YTN16 tumors. Mice were subcutaneously inoculated with 5×10⁶ YTN2 or YTN16 tumor cells. Tumor tissues (n=4) were harvested on days 4, 7 and 10; TICs were isolated and analyzed by flow cytometry. Panels show the percentages of CD3⁺ T cells (A), CD4⁺ T cells (B), CD8⁺ T cells (C), NK1.1⁺ NK cells (D), CD103⁺ DC (E), CD11b⁺ DC (F), CD64⁺Ly6C^lo macrophages (G), CD64⁺Ly6C^hi monocytes (H), and Ly6G⁺ neutrophils (I) in YTN2 tumors (open circles) and YTN16 tumors (filled circles). (J）Expression of PD-1, TIM-3, LAG-3, CTLA-4 in CD4⁺ and CD8⁺ T cells from day 14 tumors were shown. Gating strategies were shown in online supplemental figure 1. *p<0.05; **p<0.01, Student’s t-test. CTLA-4, cytotoxic T-lymphocyte-associated protein 4; DC, dendritic cell; LAG-3, Lymphocyte-activation gene 3; NK, natural killer; PD-1, Programmed cell death protein 1; TIM-3, T-cell immunoglobulin and mucin-domaincontaining-3.