Figure 1.

Kidney function is reduced, injury is increased, and tissue inflammatory processes are activated after mild ischemia and reperfusion. Rats, either Sham-operated (Sham) or subjected to 45 min of renal ischemia (I45), were sacrificed at various time points post reperfusion (R0h, R1h, R3h, R6h, R24h, R48h, R7d, and R90d). Plasma was collected to measure the creatinine (A), aspartate aminotransferase (AST) (B), and heart-fatty acid binding protein (h-FABP) (C). Kidneys were collected and analyzed for the mRNA expression of intracellular adhesion molecule-1 (ICAM-1) (D) and heat shock protein 70 (Hsp70) (E). * p <0.05, ** p < 0.01, *** p < 0.001. N = 6.