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. 2020 Oct 22;8(2):e001193. doi: 10.1136/jitc-2020-001193

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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A high C3M/PRO-C3 ratio at baseline associate with good survival outcomes. Kaplan-Meier plots demonstrating the association of the C3M/PRO-C3 ratio with progression-free survival (PFS) (A) and overall survival (OS) (B) for patients with metastatic melanoma. Patients were divided based on a C3M/PRO-C3 ratio >1 or <1 and a log-rank test was used to determine differences between survival curves. C3M, matrix metalloprotease (MMP)-degraded type III collagen; PRO-C3, N-terminal pro-peptide of type III collagen.