Figure 2.

Coronal sections of the brain showing tyrosine hydroxylase (TH)-immunoreactive fibers in four approximately equally spaced rostro-caudal levels in the five animal groups included in the study. The injection of vehicle produced no significant effect on TH immunoreactivities (A); In comparison, the intra-striatal 6-OHDA lesion caused extensive reduction in the density of TH-immunoreactive fibers, mainly in the central and lateral parts of head and tail of the caudate-putamen, leaving the medial and ventral sectors partially intact (B); Curcumin treatment protected TH-positive fiber innervation to a large extent (C); However, 6-OHDA+Cur+MLA treatment reversed the protective effect of curcumin (D) but MLA treatment alone showed no significant difference from 6-OHDA or 6-OHDA+Cur+MLA (E). Scale bar = 2 mm.