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. 2020 Oct 3;21(19):7329. doi: 10.3390/ijms21197329

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Photomicrographs of coronal sections of the midbrain showing TH immunoreactivity in three rostro-caudal levels of substantia nigra (SN) on the lesion sides. In comparison with the vehicle treatment, 6-OHDA-treated rats exhibited severe loss of TH-positive cells in the substantia nigra pars compacta (SNpc) at all levels. Curcumin-treated rats displayed significant improvements in cell survival in comparison with 6-OHDA-injected rats. MLA, an α7-receptor blocker, reversed the protective effect of curcumin in the 6-OHDA+Cur+MLA group. The MLA antagonist had no effect by itself, however, as indicated by the last animal group, 6-OHDA+MLA, which exhibited no statistical difference from the 6-OHDA+Cur+MLA group or 6-OHDA-injected rats. Scale bar = 1 mm.