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. 2020 Oct 3;21(19):7329. doi: 10.3390/ijms21197329

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relationship between apomorphine-induced rotation test and SN cell count. (A) A negative correlation in control group, with normal cell count (~100%) as reflected on number of rotation; (B) A negative correlation in 6-OHDA group with a steeper curve and a much-reduced number of surviving cells. 6-OHDA injected rats showed severe loss of TH+ve cells in the SN which affected rats’ performance in apomorphine test and in the shallower and less steep negative correlation; (C) Negative correlation in 6-OHDA+Cur group, where curcumin showed significant improvement in cells survival which was reflected significantly on apomorphine test; (D) Correlation in 6-OHDA+Cur+MLA group, MLA, an α7-receptor blocker, reversed the protective effect of curcumin in 6-OHDA+Cur+MLA group, and consequently apomorphine test results were comparable to 6-OHDA injected group.