Figure 8.

Time course of the experiments. Curcumin (200 mg/kg, per oral (P.O.))/MLA (1 µg/g, intraperitoneal (I.P.)) pretreatment was started 2 weeks before surgery. Intra-striatal injection of 6-OHDA was performed after week 2. This was followed by one-week of recovery to ensure head wound healing and allow proper animal handling for oral curcumin administration, which was continued for 2 weeks post-recovery. At the end of the 3-week total treatment period, an apomorphine-induced rotation test was conducted. Finally, animals were sacrificed, and the brains were collected for processing and data analysis.