Figure 1.

Simplified pathophysiology of acute kidney injury development in sepsis and selected antibiotic treatment [6,10,42,47,48,51,55,56]. DNA—deoxyribonucleic acid, ICAM-1—intercellular adhesion molecule-1, IKK—I-kinase, IL-6—interleukin 6, IL-8—interleukin 8, MBD2—Methyl-CpG Binding Domain Protein 2, MCP-1—monocyte chemoattractant protein 1, NF-κB—nuclear factor—kappa B, PTC—proximal tubular cells, ROS—reactive oxygen species, TLR4—Toll-like receptor 4, TNFα—tumor necrosis factor alpha