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. 2020 Oct 5;20(6):326. doi: 10.3892/ol.2020.12189

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Co-treatment of cisplatin and NVP-BEZ235 synergistically inhibits A549/DDP cell colony formation. (A) A colony formation assay was performed a, control; b, cisplatin (1.53 µg/ml); c, NVP-BEZ235 (0.15 µg/ml); d, cisplatin+NVP-BEZ235 (cisplatin: NVP-BEZ235 at 10:1, cisplatin: 1.53 µg/ml). (B) The number of colonies of A549/DDP cells was quantified after different treatment. Scale bar, 34.8 mm. Data are presented as the mean ± standard deviation (n=3). **P<0.001 vs. control group; ^##P<0.001 vs. cisplatin group. DDP, diamminedichloroplatinum resistance.