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. 2020 Oct 5;20(6):326. doi: 10.3892/ol.2020.12189

Figure 4.

Figure 4.

Co-treatment of cisplatin and NVP-BEZ235 synergistically induces A549/DDP cell apoptosis. A549/DDP cell apoptosis following treatment with (A) control, (B) cisplatin (1.53 µg/ml), (C) NVP-BEZ235 (0.15 µg/ml), (D) cisplatin + NVP-BEZ235 low dose (cisplatin:NVP-BEZ235 at 10:1; cisplatin, 1.53 µg/ml) or (E) cisplatin + NVP-BEZ235 high dose (cisplatin:NVP-BEZ235 at 10:1; cisplatin, 3.06 µg/ml) for 24 h. (F) Quantification of the rate of apoptosis. Data are presented as the mean ± standard deviation (n=3). *P<0.05 and **P<0.001 vs. control group; ##P<0.001 vs. cisplatin group. DDP, diamminedichloroplatinum resistance.