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. 2020 Oct 5;20(6):326. doi: 10.3892/ol.2020.12189

Figure 5.

Figure 5.

Co-treatment of cisplatin and NVP-BEZ235 induces cell cycle arrest at the G0G1 phase. Cell cycle distribution of A549/DDP cells following treatment with (A) control, (B) cisplatin (1.53 µg/ml), (C) NVP-BEZ235 (0.15 µg/ml) or (D) cisplatin + NVP-BEZ235 (cisplatin:NVP-BEZ235 at 10:1; cisplatin, 1.53 µg/ml) for 24 h. (E) Quantification of the cell cycle distribution. Data are presented as the mean ± standard deviation (n=3). **P<0.001 vs. control group; ##P<0.001 vs. cisplatin group. DDP, diamminedichloroplatinum resistance.