Table II.
Concentrations of cisplatin and NVP-BEZ235 at a 50% inhibition rate against A549/DDP cells for different mass ratios and the corresponding CI (n=3).
| Treatment | Concentration of cisplatin (µg/ml) 50% inhibition | Concentration of NVP-BEZ235 (µg/ml) 50% inhibition | CI50 |
|---|---|---|---|
| Cisplatin | 13.29 | – | – |
| NVP-BEZ235 | – | 1.33 | – |
| Cisplatin:NVP-BEZ235 at 15:1 | 2.23 | 0.15 | 0.28 |
| Cisplatin:NVP-BEZ235 at 10:1 | 1.53 | 0.15 | 0.23 |
| Cisplatin:NVP-BEZ235 at 5:1 | 1.28 | 0.26 | 0.29 |
| Cisplatin:NVP-BEZ235 at 1:1 | 0.58 | 0.58 | 0.48 |
| Cisplatin:NVP-BEZ235 at 1:5 | 0.16 | 0.79 | 0.61 |
CI, combination index; DDP, diamminedichloroplatinum resistance; -, not applicable.