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. 2020 Sep 29;21(19):7202. doi: 10.3390/ijms21197202

Figure 2.

Figure 2

The effect of aging on the expression of mitophagy-related genes, proteins, and oxidative phosphorylation (OXPHOS) subunits in the mouse auditory cortex. (A) The mRNA expression levels of PINK1, Parkin, BNIP3, and NIX in the mouse auditory cortex significantly decreased with aging. (B) The Western blotting analysis of PINK1, Parkin, BNIP3, COX4, LC3B, and OXPHOS subunits. β-actin was used as the loading control. (C) The relative protein expression levels of PINK1, Parkin, BNIP3, COX4, LC3B, and OXPHOS subunits I–IV in the mouse auditory cortex significantly decreased with aging. The data are shown as mean ± standard error of mean (five mice per group; 1 m, 1 month; 6 m, 6 months; 12 m, 12 months; 18 m, 18 months). * p < 0.05, ** p < 0.01, ns: not significant.