Table 5.

Outline potential adherence strategies.

	Low risk for non-adherence	Vulnerability for non-adherence: 1–2 risk factors	High risk for non-adherence: ≥3 risk factors
Patient profile	Patients with illness insight; positive attitude toward medication; family involvement and support; positive attitudes of family members toward medication	Young patients; patients who lack illness insight, cannabis use and substance dependence; high intensity of symptoms; poor premorbid functioning; negative attitude toward medication; lack of family involvement
Adherence measurement method	Subjective rating scale	Subjective rating scale + unexpected pill count + prescription renewal/refill	Subjective rating scale + unexpected pill count + prescription renewal/refill + TDM or e-monitoring
Potential intervention strategies	PE	(LAI+) PE + SMS reminders If applicable: family therapy; cessation of cannabis and other substances	LAI + PE + contingency management (incl. financial incentives) If applicable: family therapy; cessation of cannabis and other substances; technology interventions