Treatment resistance | Kane et al. (1988): (1) a minimum of three treatment periods in the preceding 5 years with antipsychotics (from at least two difference chemical classes) at dosages ≥1,000 mg/day chlorpromazine for a period of 6 weeks, each without significant symptomatic relief and (2) no period of good functioning within the preceding 5 years. Kane et al. (2019): failure to respond on any two antipsychotic medications, each at an adequate dose (i.e., equivalent to ≥600 mg/day chlorpromazine) and treatment duration + objective symptom measurements should be used to assess treatment response and medication adherence. |
Pseudo-resistance | Lack of response to antipsychotic treatment not attributed to pharmacological inefficiency of the compound but depending on modifiable and non-modifiable factors such as non-adherence (de Bartolomeis et al., 2018) |
Non-adherence | Only some or none of the prescribed medication is taken (Kane et al., 2019) |