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. 2020 Oct 23;11:452. doi: 10.1186/s13287-020-01971-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — EPSC-Exos-specific microRNAs inhibited TGF-β1 expression of HDF. a Main miRNAs in EPSC-Exos using qRT-PCR. b A list of predicted binding sites of EPSC-Exos-specific miRNAs and their targets. c, d TGF-β1 mRNA levels of HDF treated with miR-425-5p agomir and miR-142-3p agomir of HDF, respectively. Scale bar = 200 μm. *P < 0.05; ***P < 0.001; mean ± SD; n = 5. Ctrl, control; EGF, epidermal growth factor; EPSC-Exos, epidermal stem cell-derived exosomes; HDF, human dermal fibroblast; TGF-β1, transforming growth factor β-1; IF, immunofluorescence staining