Table 1.
Demographic, laboratory and haemodynamic variables.
| Controls (n = 25) | Donors (n = 23) | p value | |
|---|---|---|---|
| Demographics | |||
| Age (years) | 41 ± 10 | 46 ± 10 | 0.098 |
| Male n(%) | 18 (72) | 16 (70) | 0.853 |
| Caucasian n(%) | 15 (60) | 18 (78) | 0.173 |
| BMI (kg/m2) | 25.6 ± 2.3 | 26.8 ± 4.2 | 0.230 |
| Smoker n(%) – Current | 2 (8) | 3 (13) | 0.905 |
| Ex | 5 (20) | 4 (17) | |
| Never | 18 (72) | 16 (70) | |
| Hypertension n(%) | 1 (4) | 1 (4) | 1.0 |
| Hypercholesterolaemia n(%) | 8 (32) | 13 (57) | 0.145 |
| ACE inhibitors n(%) | 0 (0) | 1 (4) | 0.479 |
| Statin therapy n(%) | 2 (8) | 1 (4) | 1.0 |
| Time from donation (months) | n/a | 30 (24–67) | n/a |
| Laboratory data | |||
| Haemoglobin (g/l) | 146 ± 11 | 141 ± 10 | 0.198 |
| Urea (mmol/l) | 5.0 ± 1.3 | 5.7 ± 1.1 | 0.061 |
| Creatinine (μmol/l) | 80 ± 17 | 107 ± 15 | <0.001 |
| eGFR (ml/min/1.73m2) | 99 (91–112) | 68 (64–72) | <0.001 |
| ACR (mg/mmol) | 0.9 (0–2.1) | 0.9 (0–1.8) | 0.298 |
| Phosphate (mmol/l) | 1.13 ± 0.17 | 1.03 ± 0.17 | 0.042 |
| Corrected calcium (mmol/l) | 2.33 ± 0.08 | 2.36 ± 0.08 | 0.152 |
| PTH (μmol/l) | 5.7 ± 2.1 | 6.6 ± 2.0 | 0.237 |
| Total cholesterol (mmol/l) | 4.6 (4.0–5.2) | 5.1 (4.8–5.6) | 0.06 |
| LDL cholesterol (mmol/l) | 2.7 ± 1.0 | 3.2 ± 0.8 | 0.06 |
| NT-proBNP (ng/l) | 40 (22–69) | 54 (24–95) | 0.391 |
| Detectable CRP n(%) | 7 (29) | 18 (73) | 0.01 |
| hsCRP (mg/l) | 0.63 (0.41–0.86) | 1.31 (0.92–2.0) | 0.006 |
| Urate (μmol/l) | 332 ± 84 | 366 ± 82 | 0.158 |
| Renin (mIU/l) | 21.2 (16.9–35.6) | 17.9 (13.4–35.5) | 0.324 |
| Aldosterone (μmol/l) | 161 (129–225) | 129 (44–222) | 0.156 |
| Haemodynamic data | |||
| Systolic BP (mmHg) | 116 ± 11 | 115 ± 12 | 0.835 |
| Diastolic BP (mmHg) | 76 ± 10 | 76 ± 10 | 0.816 |
| Heart rate (bpm) | 71 ± 12 | 65 ± 11 | 0.066 |
Data are presented as mean ± SD or median (IQR). BMI – body mass index, ACE – angiotensin converting enzyme, eGFR – estimated glomerular filtration rate, ACR – albumin creatinine ratio, PTH – parathyroid hormone, LDL – low density lipoprotein, NT-proBNP – n terminal pro brain natriuretic peptide, CRP – C reactive peptide, hsCRP – high sensitivity C reactive peptide, BP – blood pressure.