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. 2020 Oct 23;128(10):107008. doi: 10.1289/EHP6498

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figures 5A to 5G are clustered bar graphs, depicting agonistic activity of the Tetrabromobisphenol A mono-ether structural analogs by plotting relative cell proliferation compared with Dimethyl sulfoxide (percentage), ranging from 0 to 400 in increments of 50; 0 to 270 in increments of 30, 0 to 500 in increments of 50, 0 to 160 in increments 20; 0 to 160 in increments of 20; 0 to 160 in increments of 20; and 0 to 160 in increments of 20 (y-axis) across Tetrabromobisphenol A-mono(glycidyl ether) (micromolar), Tetrabromobisphenol A-mono(allyl ether) (micromolar), Tetrabromobisphenol A-mono(2,3-dibromopropyl ether) (micromolar), Tetrabromobisphenol A (micromolar), Tetrabromobisphenol A-bis(glycidyl ether) (micromolar), Tetrabromobisphenol A-bis(allyl ether) (micromolar), and Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (micromolar), ranging from 0 to 0.6 in increments of 0.3, 0.6 to 1.2 in increments of 0.6, 1.2 to 2.5 in increments of 1.3, 2.5 to 5 in increments of 2.5, and 5 to 10 in increments of 5 (x-axis) for without amiodarone and with 2 micromolar amiodarone, respectiviely. — Agonistic activity of the tetrabromobisphenol A (TBBPA) mono-ether structural analogs [(A) TBBPA-mono(glycidyl ether) (TBBPA-MGE), (B) TBBPA-mono(allyl ether) (TBBPA-MAE), and (C) TBBPA-mono(2,3-dibromopropyl ether) (TBBPA-MDBPE)], (D) TBBPA, and the TBBPA bis-ether derivatives [(E) TBBPA-bis(glycidyl ether) (TBBPA-BGE), (F) TBBPA-bis(allyl ether) (TBBPA-BAE), and (G) TBBPA-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE)] determined by the GH3 cell proliferation assay. GH3 cells were treated with different concentrations of the tested chemicals in the presence or absence of $2.0 μ M$ amiodarone. Three replicated wells were included for each group in a 96-well plate. Error bars represent the standard deviation of three replicates. Relative cell proliferation values were calculated by dividing the absorbance value at $450 nm$ of the control group (0.1% DMSO) by that of each cell sample based on the Cell Counting Kit-8 assay. * $p < 0.05$ , compared with cell samples of the control group (0.1% DMSO). ^# $p < 0.05$ , compared with cell samples treated without $2.0 μ M$ amiodarone. The $p$ -values of the experimental data were analyzed using a one-way analysis of variance, followed by a least significant difference multiple comparisons test (IBM SPSS Statistics 20). See the summary data in Table S9. Note: DMSO, dimethyl sulfoxide.