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. 2020 Oct 23;15(10):e0241212. doi: 10.1371/journal.pone.0241212

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© 2020 Piewbang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Domestic cat hepadnavirus infection in the (A, B) lung and (C, D) heart. Representative (A, C) H&E and (B, D) DHC IHC images from cat no. 3. (A) Severe broncho-interstitial pneumonia with collapsed bronchial airways. Bar indicates 45 μm. (B) DCH-immunoreactivity signals were clearly detected in the cytoplasm of bronchial luminal (inset) and glandular epitheliums and endothelial cells of blood vessels. Bar indicates 45 μm. (C) Multifocal cardiac necrosis revealed by the pinwheel pattern (arrowheads) and focal cardiac fibrosis. (D) DCH immunopositive-signals were detected in the cytoplasm of myocardium (inset) adjacent to the pericarditis. The endothelial cells were also immunopositive (arrowhead). Bars indicate 170 μm.