Table 3. AR of selected grade 3-4 AEs.
| Grade ≥ 3 AEs | Fixed-effect AR, % (95% CI range) | Random-effect AR, % (95% CI range) | I2,%a | P value |
|---|---|---|---|---|
| Fatigue | 0.03 (0.01; 0.04) | 0.03 (0.01; 0.04) | 0 | 0.95 |
| Asthenia | 0.01 (0.00; 0.03) | 0.01 (0.00; 0.05) | 3 | 1 |
| Nausea | 0.02 (0.01; 0.04) | 0.02 (0.01; 0.04) | 0 | 1 |
| Vomiting | 0.01 (0; 0.002) | 0.01 (0; 0.002) | 0 | 0.94 |
| Diarrhea | 0.05 (0.03; 0.08) | 0.04 (0.02; 0.09) | 19 | 0.58 |
| Weight loss | 0.04 (0.02; 0.06) | 0.04 (0.02; 0.06) | 0 | 1 |
| Decreased appetite | 0.00 (0; 0.02) | 0.00 (0; 0.02) | 0 | 1 |
| Stomatitis | 0.02 (0.01; 0.04) | 0.01 (0.00; 0.30) | 90 | 0.04 |
| Mucosal inflammation | 0.02 (0.01; 0.04) | 0.02 (0.01; 0.04) | 0 | 1 |
| Rash | 0.10 (0.08; 0.13) | 0.10 (0.08; 0.13) | 0 | 0.84 |
| Pruritus | 0.01 (0; 0.02) | 0.01 (0; 0.02) | 0 | 1 |
| Hyperglycemia | 0.32 (0.28; 0.36) | 0.28 (0.21; 0.37) | 36 | 0.13 |
| Arthralgia | 0 (0; 0.32) | 0 (0; 0.32) | 0 | 1 |
*Percentage of variance between studies that is due to heterogeneity and not chance. Abbreviations: AEs, Adverse Events; AR, Absolute Risk; CI, Confidence Interval.