Table 3. Overview.
Relationships between GPi and VLa Hypothesized versus observed |
|||
---|---|---|---|
Gating [15; 41] |
Rebound [18; 22] |
Observed | |
Incidence of increase- versus decrease-type responses | Inverted. GPi increases proportional to VLa decreases | Direct. GPi increases proportional to VLa increases | Direct. Similar rates of increases found in GPi and VLa (see Table 1) |
Timing of movement-related responses | GPi leads VLa by about 2 ms | GPi leads VLa by about 100 ms | GPi lags VLa by about 43 ms (see Fig 3A) |
GPi-VLa spike-spike CCFs | Negative CCF peaks at short latency in subpopulation of pairs | CCF peaks negative at short latency followed by positive at long latency. | CCF peaks are rare (at noise rate). No net bias toward negative or positive peaks (see Fig 4A–4F and Table 2) |
GPi-VLa FR correlations (NCs) | Negative NCs are larger and/or more common | Positive NCs are larger and/or more common | Significant NCs are rare w/ no net bias toward positive or negative relationships (see Fig 4G–4H and Table 2) |
VLa FR following burst in GPi firing | VLa FR decreases at short latency (about 2 ms) | VLa FR decreases following burst onset | Long-lasting (>200 ms) VLa decrease w/ pause part of GPi burst-pause complex (see Fig 5) |
VLa FR following pauses in GPi firing | VLa FR increases at short latency (about 2 ms) | VLa FR increases at short latency |
Abbreviations: CCF, cross-correlation function; FR, firing rate; GPi, globus pallidus-internus; NC, noise correlation; VLa, ventrolateral anterior nucleus; w/, with