Table 7.
Effects of taurine supplementation on inflammatory gene expression in the liver of LPS-challenged broilers1
| Treatment2 | |||||
|---|---|---|---|---|---|
| Item3 | CON | LPS | LPS + T1 | LPS + T2 | P-value |
| TLR4 | 1.00 ± 0.15b | 1.40 ± 0.10a | 0.90 ± 0.07b | 1.05 ± 0.11b | 0.021 |
| IL-1β | 1.00 ± 0.13b | 2.09 ± 0.24a | 1.31 ± 0.12b | 1.48 ± 0.17b | 0.001 |
| TNF-α | 1.00 ± 0.16b | 1.56 ± 0.10a | 1.01 ± 0.17b | 1.13 ± 0.12b | 0.030 |
| IL-6 | 1.00 ± 0.15b | 1.99 ± 0.42a | 1.16 ± 0.20b | 1.31 ± 0.19ab | 0.062 |
| COX-2 | 1.00 ± 0.25b | 1.74 ± 0.12a | 1.12 ± 0.07b | 1.20 ± 0.11b | 0.010 |
| iNOS | 1.00 ± 0.17b | 1.57 ± 0.23a | 0.99 ± 0.11b | 1.02 ± 0.06b | 0.033 |
| IL-10 | 1.00 ± 0.20 | 0.84 ± 0.06 | 0.92 ± 0.12 | 0.96 ± 0.23 | 0.923 |
1Data are means ± SEM, n = 8.
2CON, control basal diet; LPS, LPS challenged broilers fed CON; LPS+T1, LPS challenged broilers fed CON supplemented with 5 g/kg taurine; LPS+T2, LPS challenged broilers fed CON supplemented with 7.5 g/lg taurine.
3Expressed in arbitrary units. The expression of each target gene for the CON group was assigned a value of 1 and normalized against beta-actin.
a,bMeans within the same row with no common superscript differ significantly (P < 0.05).