Figure 2.

(A) Histogram depicting the quantified adsorption of recombinant α-Syn on different Ab-modified pCBMA@Fe₃O₄ MBs surfaces. The commercial carboxylic acid-terminated MBs were used as the control. (B) SEM image of serum-captured exosomes on anti-L1CAM-modified MBs versus anti-HA (control)-modified MBs (insert). Scale bar 1 μm. (C) Immunoblotting of lysates of immunocaptured vesicles confirming the detection of both transmembrane proteins (L1CAM, CD81) and internal protein Synt-1 from exosomes. Specific electrochemiluminescence detection of α-Syn (D) in neuronal exosomes immunocaptured from serum with anti-L1CAM vs anti-HA (control)-modified pCBMA@Fe₃O₄ MBs.