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. 2020 Sep 21;59(41):4003–4014. doi: 10.1021/acs.biochem.0c00443

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This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

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Solid-state magic-angle spinning ¹³C NMR spectra of uniformly ¹³C-labeled Δtau187 aggregates formed in the presence of HMWH or 6-O- or 2-O-desulfated HMWH derivatives. (A) Top: region of a ¹³C–¹³C dipolar correlation NMR spectrum of [U–¹³C] Δtau187 aggregates formed in the presence of HMWH. Dipolar interactions were reintroduced by a 5 ms DARR mixing period. Bottom: A ¹H–¹³C INEPT spectrum of the sample. (B) The ¹³C–¹³C dipolar correlation NMR spectrum and INEPT spectrum of tau filaments formed in the presence of HMW-2OH. The MAS frequency was 13 kHz in all experiments.