Table 1.

DBT and MRI guided DOT clinical trials performed in > 20 subjects and including women with breast abnormalities.

Imaging Modality	1 st Author	Year Pub.	Patients {lesions}	Objectives	Key Results
DBT	Fang, Q.	2011	125 {189}	Explore the optical and physiologic properties of normal and lesion-bearing breasts	Bulk tissue THb (n = 138 normal breasts) 19.2 μM and sO2 0.73. Cancer THb (n = 26) significantly greater than fibroglandular tissue of the same breast (P=.0062). Solid benign lesions (n=17) and cysts (n = 8) significantly lower THb than cancers (P = .025 and P = .0033, respectively).
CEMRI-	Mastanduno, MA.	2015	30	Differentiation benign vs. malignant abnormalities, operating characteristics	THb and TOI*: sig differences cancer vs. benign, combined MRI & TOI: AUC 0.95, sens 95 %, spec 89 %, PPV 95 %, NPV 89 %
CEMRI, MRI (T2, DWI)	Feng, J.	2017	24	Operating characteristics: (T2,DWI) MRI-DOT vs. CEMRI-DOT vs. CEMRI	CEMRI: AUC 0.81, sens 94 %, spec 63 %, acc 88 % T2-DWI T2-MRI DOT: AUC 0.95, sens 94 %, spec 100 %, acc 96 %, CEMRI-DOT: AUC .94, sens 88 %, spec 88 %, acc 88 %