Table 4.

Association of H. pylori and H. pylori-CagA Sero-Prevalence with Year of Birth, Overall and by Cohort, in a Subset of the H. pylori-Colorectal Cancer Consortium (NYUWHS, PLCO, SCCS, and MEC), 1985–2009

		H. pylori +			H. pylori + CagA +
Cohort	n	PRa	95% CIa	Ptrenda	PRa	95% CIa	Ptrenda
All
Whitesb	1,908	0.83	0.77, 0.91	<0.001	0.83	0.75, 0.93	0.001
African American	1,023	1.01	0.97, 1.05	0.625	1.04	1.00, 1.09	0.078
NYUWHS
Whitesb	412	0.79	0.69, 0.90	<0.001	0.76	0.62, 0.92	0.006
African American	55	0.99	0.74, 1.31	0.920	0.92	0.66, 1.29	0.630
PLCO
Whitesb	1,098	0.85	0.74, 0.98	0.020	0.85	0.71, 1.03	0.094
African American	98	1.03	0.81, 1.30	0.815	1.13	0.82, 1.55	0.449
SCCS
Whitesb	172	0.92	0.80, 1.06	0.258	1.07	0.83, 1.39	0.589
African American	590	1.02	0.97, 1.06	0.447	1.03	0.98, 1.09	0.231
MEC
Whitesc	226	0.82	0.65, 1.05	0.120	0.92	0.67, 1.28	0.635
African American	280	0.94	0.86, 1.02	0.120	0.98	0.89, 1.07	0.609
Japanese American	570	0.78	0.70, 0.87	<0.001	0.72	0.63, 0.83	<0.001
Latino	329	0.98	0.91, 1.07	0.667	0.96	0.85, 1.09	0.538
Native Hawaiian	96	1.04	0.77, 1.40	0.810	1.06	0.77, 1.45	0.739

Abbreviations: +, sero-positive; CagA, Cytotoxin-associated gene A; CI, confidence interval; MEC, Multiethnic cohort study; n, number; NYUWHS, New York University Women’s Health Study; PLCO, Prostate, Lung, Colorectal, and Ovarian Cancer Screening Study; PR, prevalence ratio; SCCS, Southern Community Cohort Study.

^aPR and 95% CI estimated for one increment increase in year of birth category (<1925, 1925-1935, 1936-1945, 1946-1953, and ≥1954) estimated by Log-binomial regression adjusted for sex, education (≤HS, technical school or some college, ≥college), and case control status; for each cohort the lowest year of birth category was considered as reference.

^bIncludes both non-Latino and Latino whites.

^cNon-Latino whites only.