. 2020 Sep 28;22(10):495–499. doi: 10.1021/acscombsci.0c00173

Table 1. Reaction Conditions for the Three-Component Petasis Reaction Using the Gewald Reaction Product 2a.

entry	solvent	time (h)	conversion (%)^a
1^b	CH₂Cl₂	24	24
2^b	HFIP	1	37
3^b	MeCN	6	13
4^b	EtOH	12	trace
5^b	THF	24	trace
6^c	CH₂Cl₂	1	48
7^c	HFIP	1	63

Monitored by LC–MS.

Amine 2a and aldehyde 3a were stirred for 10 min before boronic acid 4a was added .

Simultaneous addition of all three components.