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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Evol Hum Behav. 2020 Apr 14;41(5):330–340. doi: 10.1016/j.evolhumbehav.2020.04.001

TABLE 2. Suspected mismatch diseases.

Adapted from Lieberman (2013: Table 3). Diseases in italics have been observed in contemporary subsistence populations.

Acid reflux/chronic heartburn Depression (Major) Irritable bowel syndrome
Acne vulgaris Diabetes (Type 2) Lactose intolerance
Alzheimer’s Disease Diaper rash Lower back pain
Anxiety Eating disorders Malocclusion
Apnea Emphysema Metabolic syndrome
Atherosclerosis Endometriosis Multiple sclerosis
Athlete’s foot Fatty liver syndrome Myopia
Atopy (allergies, asthma) Fibromyalgia Obsessive-compulsive disorder
Attention deficit hyperactivity disorder Flat feet Osteoporosis
Bunions Glaucoma Plantar fasciitis
Cancers (ovarian, prostate) Gout Polycystic ovarian syndrome
Carpal tunnel syndrome Hammer toes Preeclampsia
Cavities Hemorrhoids Rickets
Chronic fatigue syndrome Hypertension Scurvy
Cirrhosis Iodine deficiency Stomach ulcers
Constipation (chronic) Impacted wisdom teeth
Crohn’s disease Insomnia (chronic)