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. Author manuscript; available in PMC: 2020 Oct 23.
Published in final edited form as: Mol Neurobiol. 2018 Oct 18;56(6):4492–4517. doi: 10.1007/s12035-018-1390-4

Figure 4. Clustering analyses: panels of clustered downregulated genes.

Figure 4.

The union of the top 50 differentially expressed L1000 genes per seed gene knockdown signature were clustered in iLINCS via Pearson correlation coefficients (n=260 genes due to gene overlap). Panels of clustered downregulated genes were selected using the dendrogram clustering function (based on Pearson correlation coefficient) and fold change/p-values were exported to Excel. Phosphofructokinase liver type (PFKL); PFK muscle type (PFKM); G lucose-6-phosphate isomerase (GPI); 6-phosphofructo-2-kinase (PFKFB2); lactate dehydrogenase A (LDHA); hexokinase 1 (HK1).