Table 1. Seed profile for bioinformatic analyses.
Summary of metabolic findings from cell-level human postmortem studies and literature. Pyramidal neuron (PN), glucose phosphate isomerase (GPI), hexokinase 1 (HK1), phosphofructokinase muscle and liver type (PFKM, PFKL), lactate dehydrogenase A (LDHA), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2).
Target | Main finding | Source |
---|---|---|
GPI | decrease PN mRNA | New finding (Figure 2) |
HK1 | decrease PN mRNA | Sullivan, C. 2018 |
PFKM | decrease PN mRNA | Sullivan, C. 2018 |
PFKL | decrease PN mRNA | New finding (Figure 2) |
LDHA | increase in lactate in ACC increase in lactate in DLPFC decrease dentate granule neuron mRNA | Rowland, R. Sullivan, C. 2018 (abstract) Altar, C. 2005 |
PFKFB2 | genetic linkage and function | Stone, W. 2004 |