Table 2. Summary of experimental changes and “lookup” replication studies.

Summary of region and cell-level seed gene findings from this human postmortem study and online databases. Mount Sinai database compares microarray data from the dorsolateral prefrontal cortex in schizophrenia (n=16) and control (n=15) subjects. Stanley Medical Research Institute (SMRI) Genomics database compares microarray and consortium data from schizophrenia (n=50) and control (n=50) subjects from 5 postmortem brain regions (BA6, BA8/9, BA10, BA46, cerebellum). The cortical neuron mRNA is a publicly available dataset comparing mRNA from inducible pluripotent stem cells from schizophrenia and control patients differentiated in frontal cortical neurons. Stanley Medical Research Institute (SMRI) Online Genomics Database, Mount Sinai School of Medicine (MSSM) dorsolateral prefrontal cortex (DLPFC), fold change (FC), glucose phosphate isomerase (GPI), hexokinase 1 (HK1), phosphofructokinase muscle and liver type (PFKM, PFKL), lactate dehydrogenase A (LDHA), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2). All results are presented as diseased state versus control. Red text indicates finding was significant according to p-value cut off of 0.05 and/or fold change cut off of 1.1.

Target	Human DLPFC mRNA	Pyramidal Neurons mRNA	Cortical Neurons mRNA	SMRI Genomics mRNA	MSSM
LDHA15	−1.15 FC, p=0.35918	−1.11 FC, p=0.28518	−1.64 FC#	−1.11 FC, p=0.022	−1.06 FC, p=0.320
HK1	1.10 FC, p=0.39718	−1.24 FC, p=0.00318	−1.99 FC#	1.12 FC, p=0.065	−1.01 FC, p=0.831
PFKM	−1.32 FC, p=0.03918	−1.43 FC, p=0.000118	1.24 FC#	1.05 FC, p=0.225	1.03 FC, p=0.694
PFKL	NM	−1.27 FC, p=0.011	−2.00 FC#	−1.00 FC, p=0.920	−1.03 FC##
PFKFB214	NM	−1.07 FC, p=0.57318	−1.09 FC#	1.00 FC, p=0.975	−1.31 FC##
GPI	NM	−1.26 FC, p=0.015	−1.97 FC#	−1.01 FC, p=0.659	−1.01 FC, p=0.878

^#denotes unavailable p statistics due to low subject number.

^##denotes multiple affy probes for the same gene (geomean was used to calculate fold change).

^*P<0.05 and FC>1.10.