Table 3. Summary of Enrichr analyses.

Hits and biological function for Enrichr analyses of panels of clustered upregulated and downregulated genes from iLINCS clustering analysis.

PANELS OF CLUSTERED UPREGULATED GENE ANALYSIS
Analysis	Select Targets	Function
KEGG Signaling Pathways	FOXO, MAPK, Wnt	cell metabolism, inflammation, cell growth, mitochondrial function
Protein-Protein Interactions	RPS6KA3, MAPK14, GSK3B, CDK1, CUL1, SKP1, PCNA, HDAC1, ESR1	metabolism, cell proliferation, degradation/ubiquitination, chromatin remodeling
Kinases	AKT1, MAP2K2, PTK2, ATR, NMUR2, FFAR1	glucose metabolism, cell cycle regulation, energy homeostasis
Transcription Factors	WT1, TRIM28, NFIB, NUCKS1, TCF3, ESR1, ESR2, ELK3, CEBPB	developmental processes, immune response, estrogen receptors
PANELS OF CLUSTERED DOWNREGULATED GENE ANALYSIS
KEGG Signaling Pathways	p53 signaling, HTLV infection, hepatitis B	inflammation, impaired immunity, and cell proliferation
Protein-Protein Interactions	HDAC2, HDAC1, PCNA, BRCA1, CREBBP, CSNK2A1, NFKB2, MYC	Chromatin remodeling/HDAC inhibitors, immunity/cell cycle regulation, ubiquitination
Kinases	PPARγ, RXR, PXK, ABL2, RYK, WEE1, LPHN1, NR3C1, GPR37	CNS development, cell cycle progression, cytoskeletal remodeling carbohydrate/fatty acid metabolism, inflammation
Transcription Factors	MYC, MYCN, NUCKS1, FOXM1, E2F1, E2F4, POU5F1, EKLF	cellular proliferation and cell cycle control, development