Table 4. Top 12 unique chemical perturbagens.
The top unique chemical perturbagens with the ability to “reverse” the schizophrenia bioenergetic profile.
| Description | |
|---|---|
| Valproic acid | Histone deacetylase (HDAC) inhibitor, voltage-gated sodium channel blocker |
| Trifluoperazine | Typical antipsychotic drug |
| C23H24O8, “Wortmannin” | Irreversible phosphoinositide 3-kinase (PI3K) inhibitor, mitogen-activated protein kinase (MAPK) inhibitor at high concentrations |
| Thioridazine | Typical antipsychotic drug |
| ST013886 | Estradiol |
| Tretinoin | Medication used for the treatment of acne and acute promyelocytic leukemia (APL), prevents APL cells from proliferating |
| Troglitazone | Ligand to both PPARa and more strongly PPARy, thiazolidinedione (TZD) drug class, reduces inflammation, enhances insulin sensitivity |
| Fluphenazine | Typical antipsychotic drug |
| MLS001214919 | Small molecule |
| Genistein | Isoflavone with antioxidant abilities, activates PPAR isoforms α, δ, and γ |
| LY-294002 | Strong (reversible) inhibitor of phosphoinositide 3-kinases (PI3Ks) |
| MLS002473819 | Small molecule |